Advancing Breast Cancer Research
The mission of the Catherine Peachey Fund is to promote advances in breast cancer research and treatment. We provide financial support to research and programs that we believe are best positioned to move from the bench to the clinic, and impact patient clinical outcomes.
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The Catherine Peachey Fund has provided nearly $4 million dollars to breast cancer research and programs in Indiana, making a global impact.
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The fund is unique in its efficient funding process and is fully staffed by volunteers. We operate at near zero operating costs so that all funds raised go directly to research.
Current Projects
The Catherine Peachey Fund has invested nearly $4 million to breast cancer research and projects in Indiana.
Investigating DCIS to IDC transition and associated disparities in breast cancer
Led by Crislyn D’Souza-Schorey, PhD, at the University of Notre Dame, this research aims to investigate changes in the breast cancer microenvironment that lead to the development of IDC. Ancestry-dependent differences in breast cancer tissues will be examined to elucidate the molecular mechanisms underlying the aggressive nature of IDC observed in more vulnerable patient cohorts.
It will serve as the foundation for future applications aimed at identifying the most effective treatments and surveillance strategies for women with invasive breast cancer, particularly those at higher risk.
An RNA-based medicine for the treatment of triple negative breast cancer
Led by Andrea Kasinski, PhD at Purdue University, this project focuses on advancing a stabilized version of the tumor suppressive miRNA, miRNA 34a, for the treatment of triple negative breast cancer (TNBC).
The data from this award will allow identification of the most promising modification pattern and determine its efficacy when conjugated to folate-NADS in a TNBC xenograft model, providing critical insights in pharmokinetics and therapeutic potential.
Impact of living at high altitude regions on breast cancer progression
Led by Hari Nakshatri, PhD, and his collaborators, Robert Tepper, PhD and Mark Kaplan, PhD, all at Indiana University, this pilot project tests the effects of conditioning to low oxygen levels on breast cancer growth and metastasis, particularly to lungs.
This study will provide an opportunity to perform future studies in patients from high altitude and sea level places for tumor growth patterns and response to treatments including immunotherapy.
